Significance adds value to pharma and academic stakeholders by leading and supporting Evidence Generation Strategies and Real World Evidence research.
Services
Not sure which of these is yours? Take a maturity assessment — a few minutes, immediate results.
Why Significance
Having designed evidence strategies and led multinational Real World Evidence studies in global pharma, we understand firsthand the goals and challenges organisations face in generating impactful Real World Evidence and evidence generation strategies — and how to navigate them.
Our vision is a future where evidence-based decisions lead to better health outcomes for patients worldwide. That belief shapes every engagement: evidence is not a compliance exercise or a box to tick. It is the bridge between a medicine’s scientific story and the decisions that determine how patients access it.
Contact us
Tell us where your evidence stands today and where it needs to take you — we will map the way forward together, at your pace.
Services
Outline it in a few lines, and we will advise candidly on whether — and how — Significance can help.
Self-assessment
A structured self-assessment built from the inside view of how pharma RWE functions actually operate. A few minutes, immediate results, nothing stored or transmitted.
How mature is your organisation’s evidence generation capability — across team development, operational excellence, cross-functional collaboration and strategic fit? A structured self-assessment with a scored result and an interpretation of where to focus first.
Runs entirely in your browser. Nothing you answer is stored or transmitted — the result is for you.
Advisory
Sometimes you do not need a project — you need an hour with someone who has done this before.
We offer a paid one-hour advisory call for questions that deserve a prepared, expert answer rather than a sales pitch: a study design you want challenged, an evidence strategy you want pressure-tested, a governance or process question, a data source decision — or anything in between.
Fixed fee of [INSERT FEE], invoiced normally. No retainer, no follow-up obligation, no upsell — and if we think a call will not actually help your case, we will tell you so before you book.
About
Significance exists because of a pattern we watched for years from the client side of the table.
We started Significance after a decade of experience in global pharmaceutical companies — working across Clinical Trials, Real World Data analytics, leading multinational Real World Evidence studies and designing global evidence generation strategies and frameworks. The common denominator across all of it: generating scientific evidence that supports the value of life-changing medicines, from genomics and pre-clinical data to observational research and health economics modelling.
In those years, we hired and worked with a number of external support providers — from the world’s largest CROs to small boutique consultancies. Those experiences gave us a clear picture of what a genuinely useful advisory partner looks like, and what is consistently missing. We decided to build it.
Significance embodies all the traits of an ideal partner: adaptable, deeply understanding of client needs, willing to go the extra mile, and eager to share knowledge. Not a vendor executing a brief — a partner invested in the outcome.
Philosophy
A study that does not change a decision is a cost, not an asset. Every engagement starts by naming the decision the evidence has to support — and is judged against it.
No inflated frameworks, no proprietary acronyms, no forty-slide answers to ten-slide questions. The science should be airtight; everything around it should be simple.
If the right answer is a smaller project — or no project — that is the answer you will get. Long-term trust is worth more than any single scope of work.
An initial conversation is usually enough to establish whether Significance is the right fit — with a straightforward answer either way.
Contact
You do not need a polished brief. Tell us, in plain terms, what decision you are trying to support, what is making it hard, and where you are in the process. That is enough for a first conversation — and the first conversation is always free of charge and free of pressure.
Looking for the paid one-hour advisory call? Details here.
Prefer email?
We reply personally, usually within two working days. Your message goes to a person, not a pipeline.